Theoretically, the effect of refractive status may be explained by artefacts of RNFLT measurement circle placement. The effect on global RNFLT of a difference in refractive error of 10 diopters corresponded to the effect of a difference in age of 60 years. RNFLT as measured by Stratus OCT standard protocols was significantly affected by age and refractive status. These effects varied between measurement sectors. RNFLT decreased by 2.6–2.9 μm per increasing decade of age and increased by 1.5–1.8 μm per more positive diopter of spherical equivalent using full-circle measurements of the three standard protocols. In multivariate analyses only age in combination with refractive error, or with axial length, was significant and explained 14.7–17.6% ( R 2) of the total variation of RNFLT, approximately 50% more than age alone. ResultsĪge, refractive error, axial length, and lens nuclear colour and opalescence affected RNFLT in univariate analyses, whereas gender, IOP, and optic disc size had no significant effect. Effects on RNFLT of age, gender, refractive error, axial length, lens nuclear colour and opalescence, intra-ocular pressure (IOP), and optic disc size were examined by univariate and multivariate analyses. Stratus OCT RNFLT was measured by three standard protocols, two with high and one with standard image resolution. Participants underwent an extensive eye examination. We included 178 healthy eyes of 178 subjects between 20 and 80 years of age. With this perspective we evaluated the isolated and combined effects of factors potentially affecting the Stratus OCT RNFLT measurements in healthy subjects. The variation in retinal nerve fibre layer thickness (RNFLT) as measured by Stratus optical coherence tomography (OCT) in healthy subjects may be reduced when the effect on RNFLT measurements of factors other than disease is corrected for, and this may improve the diagnostic accuracy in glaucoma.
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